Melanoma skin cancer remains incurable, and targeting heat shock protein 90 (Hsp90) is a promising therapeutic approach. In this study, we investigated the effects of 17-aminogeldanamycin, a potent inhibitor of Hsp90, the nuclear factor-kappa B (NF-kB) activity in a patient-derived melanoma cell lines and NRASQ61R BRAFV600E.

We did a time-lapse microscopy and flow cytometry to monitor changes in cell meeting and survival. NF-kB activity is determined by Immunodetection of phospho-p65 and assessment of gene expression of NF-kB dependent by quantitative real-time polymerase chain reaction (qRT-PCR), Western blotting and enzyme-linked immunosorbent assay (ELISA).

constitutive activity of p65 / NF-kB was evident in all melanoma cell lines. The difference in rates may be linked to genetic changes in CHUK, IL1B, MAP3K14, NFKBIE, RIPK1, and TLR4, while the difference in the level of gene transcripts-induced NF-kB revealed by PCR arrays that may arise from the contribution of other regulatory mechanisms. 17-Aminogeldanamycin markedly reduced levels of phospho-p65, but the level of total p65 protein is not changed, indicating that the 17-aminogeldanamycin inhibits activation of p65 / NF-kB.

This conclusion is supported by a significantly reduced expression of selected genes of NF-kB-dependent: cyclin D1 (CCND1), CXC motif chemokine ligand 8 (CXCL8), and vascular endothelial growth factor (VEGF), as shown in the level of transcript and protein, as well as the secretion of IL-8 and VEGF. Our studies show that 17-aminogeldanamycin can be used for efficient inhibition of NF-kB activity and a simultaneous decrease in the level of IL-8 and VEGF in melanoma extracellular environment.

Baicalin Inhibits Proliferation and inflammatory cytokine Cells Induced by Tumor Necrosis Factor α (TNF-α) in Human immortalized keratinocytes (HaCaT) Human keratinocytes by Inhibiting STAT3 / Nuclear Factor kappa B (NF-kB) Signaling Pathway.

BACKGROUND baicalin is isolated flavonoids from Scutellaria baicalensis roots and used in traditional Chinese medicine. Psoriasis is a persistent skin disease and chronic recurrent inflammation that is characterized by inflammation and increasing keratinocyte proliferation. This study aimed to investigate the effects of baicalin on HaCaT immortalized human keratinocytes in vitro and molecular mechanisms involved.

MATERIALS AND METHODS HaCaT keratinocytes cultured in increasing concentrations of baicalin at 6.25 pM, 12.5 pM, and 25 pM. Psoriasis established in vitro model using HaCaT cells were treated with tumor necrosis factor-alpha (TNF-alpha). MTT assay was used to asses cell viability and apoptosis.

Thrombin Receptor Activator
MBS3610879-50mg	MyBiosource	50mg	EUR 735

Thrombin Receptor Activator
MBS3610879-5mg	MyBiosource	5mg	EUR 295

Thrombin Receptor Activator
MBS3610879-5x50mg	MyBiosource	5x50mg	EUR 2995

SRA1, CT (SRA1, Steroid receptor RNA activator 1, Steroid receptor RNA activator protein)
MBS649986-02mL	MyBiosource	0.2mL	EUR 695

SRA1, CT (SRA1, Steroid receptor RNA activator 1, Steroid receptor RNA activator protein)
MBS649986-5x02mL	MyBiosource	5x0.2mL	EUR 2975

SRA1, CT (SRA1, Steroid receptor RNA activator 1, Steroid receptor RNA activator protein) (AP)
MBS6351015-02mL	MyBiosource	0.2mL	EUR 980

SRA1, CT (SRA1, Steroid receptor RNA activator 1, Steroid receptor RNA activator protein) (AP)
MBS6351015-5x02mL	MyBiosource	5x0.2mL	EUR 4250

SRA1, CT (SRA1, Steroid receptor RNA activator 1, Steroid receptor RNA activator protein) (PE)
MBS6351025-02mL	MyBiosource	0.2mL	EUR 980

SRA1, CT (SRA1, Steroid receptor RNA activator 1, Steroid receptor RNA activator protein) (PE)
MBS6351025-5x02mL	MyBiosource	5x0.2mL	EUR 4250

SRA1, CT (SRA1, Steroid receptor RNA activator 1, Steroid receptor RNA activator protein) (APC)
MBS6351016-02mL	MyBiosource	0.2mL	EUR 980

SRA1, CT (SRA1, Steroid receptor RNA activator 1, Steroid receptor RNA activator protein) (APC)
MBS6351016-5x02mL	MyBiosource	5x0.2mL	EUR 4250

SRA1, CT (SRA1, Steroid receptor RNA activator 1, Steroid receptor RNA activator protein) (FITC)
MBS6351018-02mL	MyBiosource	0.2mL	EUR 980

SRA1, CT (SRA1, Steroid receptor RNA activator 1, Steroid receptor RNA activator protein) (FITC)
MBS6351018-5x02mL	MyBiosource	5x0.2mL	EUR 4250

SRA1, CT (SRA1, Steroid receptor RNA activator 1, Steroid receptor RNA activator protein) (Biotin)
MBS6351017-02mL	MyBiosource	0.2mL	EUR 980

SRA1, CT (SRA1, Steroid receptor RNA activator 1, Steroid receptor RNA activator protein) (Biotin)
MBS6351017-5x02mL	MyBiosource	5x0.2mL	EUR 4250

Adenosine A1 receptor activator T62
HY-106199	MedChemExpress	1 mg	EUR 422.08
Description: Adenosine A1 receptor activator T62 is an allosteric enhancer of adenosine A1 receptor. Adenosine A1 receptor activator T62 produces antinociception in animal models of acute pain and also reduces hypersensitivity in models of inflammatory and nerve-injury pain[1][2][3].

Adenosine A1 receptor activator T62
MBS5754481-10mg	MyBiosource	10mg	EUR 535

Adenosine A1 receptor activator T62
MBS5754481-1mg	MyBiosource	1mg	EUR 220

Adenosine A1 receptor activator T62
MBS5754481-25mg	MyBiosource	25mg	EUR 865

Adenosine A1 receptor activator T62
MBS5754481-2mg	MyBiosource	2mg	EUR 280

Adenosine A1 receptor activator T62
MBS5754481-5mg	MyBiosource	5mg	EUR 380

Adenosine A1 receptor activator T62
T14127-10mg	TargetMol Chemicals	10mg	Ask for price
Description: Adenosine A1 receptor activator T62

Adenosine A1 receptor activator T62
T14127-1g	TargetMol Chemicals	1g	Ask for price
Description: Adenosine A1 receptor activator T62

Adenosine A1 receptor activator T62
T14127-1mg	TargetMol Chemicals	1mg	Ask for price
Description: Adenosine A1 receptor activator T62

Adenosine A1 receptor activator T62
T14127-50mg	TargetMol Chemicals	50mg	Ask for price
Description: Adenosine A1 receptor activator T62

Adenosine A1 receptor activator T62
T14127-5mg	TargetMol Chemicals	5mg	Ask for price
Description: Adenosine A1 receptor activator T62

RANK (Receptor Activator of NFkB) (AP)
MBS6248266-01mL	MyBiosource	0.1(mL	EUR 995

RANK (Receptor Activator of NFkB) (AP)
MBS6248266-5x01mL	MyBiosource	5x0.1mL	EUR 4325

RANK (Receptor Activator of NFkB) (PE)
MBS6252141-01mL	MyBiosource	0.1(mL	EUR 995

RANK (Receptor Activator of NFkB) (PE)
MBS6252141-5x01mL	MyBiosource	5x0.1mL	EUR 4325

SRA1, CT (SRA1, Steroid receptor RNA activator 1, Steroid receptor RNA activator protein) (MaxLight 405)
MBS6351020-01mL	MyBiosource	0.1mL	EUR 980

SRA1, CT (SRA1, Steroid receptor RNA activator 1, Steroid receptor RNA activator protein) (MaxLight 405)
MBS6351020-5x01mL	MyBiosource	5x0.1mL	EUR 4250

SRA1, CT (SRA1, Steroid receptor RNA activator 1, Steroid receptor RNA activator protein) (MaxLight 490)
MBS6351021-01mL	MyBiosource	0.1mL	EUR 980

SRA1, CT (SRA1, Steroid receptor RNA activator 1, Steroid receptor RNA activator protein) (MaxLight 490)
MBS6351021-5x01mL	MyBiosource	5x0.1mL	EUR 4250

SRA1, CT (SRA1, Steroid receptor RNA activator 1, Steroid receptor RNA activator protein) (MaxLight 550)
MBS6351022-01mL	MyBiosource	0.1mL	EUR 980

SRA1, CT (SRA1, Steroid receptor RNA activator 1, Steroid receptor RNA activator protein) (MaxLight 550)
MBS6351022-5x01mL	MyBiosource	5x0.1mL	EUR 4250

SRA1, CT (SRA1, Steroid receptor RNA activator 1, Steroid receptor RNA activator protein) (MaxLight 650)
MBS6351023-01mL	MyBiosource	0.1mL	EUR 980

SRA1, CT (SRA1, Steroid receptor RNA activator 1, Steroid receptor RNA activator protein) (MaxLight 650)
MBS6351023-5x01mL	MyBiosource	5x0.1mL	EUR 4250

SRA1, CT (SRA1, Steroid receptor RNA activator 1, Steroid receptor RNA activator protein) (MaxLight 750)
MBS6351024-01mL	MyBiosource	0.1mL	EUR 980

SRA1, CT (SRA1, Steroid receptor RNA activator 1, Steroid receptor RNA activator protein) (MaxLight 750)
MBS6351024-5x01mL	MyBiosource	5x0.1mL	EUR 4250

RANK (Receptor Activator of NFkB) (HRP)
MBS6251200-01mL	MyBiosource	0.1(mL	EUR 995

RANK (Receptor Activator of NFkB) (HRP)
MBS6251200-5x01mL	MyBiosource	5x0.1mL	EUR 4325

RANK (Receptor Activator of NFkB) (APC)
MBS6269117-01mL	MyBiosource	0.1mL	EUR 995

RANK (Receptor Activator of NFkB) (APC)
MBS6269117-5x01mL	MyBiosource	5x0.1mL	EUR 4325

RANK (Receptor Activator of NFkB) (FITC)
MBS6250181-01mL	MyBiosource	0.1(mL	EUR 995

RANK (Receptor Activator of NFkB) (FITC)
MBS6250181-5x01mL	MyBiosource	5x0.1mL	EUR 4325

Thrombin Receptor Activator for Peptide
MBS5764930-10mg	MyBiosource	10mg	EUR 290

Thrombin Receptor Activator for Peptide
MBS5764930-1mg	MyBiosource	1mg	EUR 155

Thrombin Receptor Activator for Peptide
MBS5764930-25mg	MyBiosource	25mg	EUR 465

Thrombin Receptor Activator for Peptide
MBS5764930-2mg	MyBiosource	2mg	EUR 180

Thrombin Receptor Activator for Peptide
MBS5764930-5mg	MyBiosource	5mg	EUR 220

Thrombin Receptor Activator for Peptide
MBS3610993-10mg	MyBiosource	10mg	EUR 355

Thrombin Receptor Activator for Peptide
MBS3610993-25mg	MyBiosource	25mg	EUR 530

Thrombin Receptor Activator for Peptide
MBS3610993-50mg	MyBiosource	50mg	EUR 705

Thrombin Receptor Activator for Peptide
MBS3610993-5mg	MyBiosource	5mg	EUR 285

Thrombin Receptor Activator for Peptide
MBS3610993-5x50mg	MyBiosource	5x50mg	EUR 2855

Thrombin Receptor Activator for Peptide
MBS5758390-10mg	MyBiosource	10mg	EUR 300

Thrombin Receptor Activator for Peptide
MBS5758390-1mg	MyBiosource	1mg	EUR 160

Thrombin Receptor Activator for Peptide
MBS5758390-25mg	MyBiosource	25mg	EUR 475

Thrombin Receptor Activator for Peptide
MBS5758390-50mg	MyBiosource	50mg	EUR 675

Thrombin Receptor Activator for Peptide
MBS5758390-5mg	MyBiosource	5mg	EUR 225

Thrombin Receptor Activator for Peptide
T7674-10mg	TargetMol Chemicals	10mg	Ask for price
Description: Thrombin Receptor Activator for Peptide

Thrombin Receptor Activator for Peptide
T7674-1g	TargetMol Chemicals	1g	Ask for price
Description: Thrombin Receptor Activator for Peptide

Thrombin Receptor Activator for Peptide
T7674-1mg	TargetMol Chemicals	1mg	Ask for price
Description: Thrombin Receptor Activator for Peptide

Thrombin Receptor Activator for Peptide
T7674-50mg	TargetMol Chemicals	50mg	Ask for price
Description: Thrombin Receptor Activator for Peptide

Thrombin Receptor Activator for Peptide
T7674-5mg	TargetMol Chemicals	5mg	Ask for price
Description: Thrombin Receptor Activator for Peptide

SRA1, CT (SRA1, Steroid receptor RNA activator 1, Steroid receptor RNA activator protein) (Azide free) (HRP)
MBS6351019-02mL	MyBiosource	0.2mL	EUR 980

SRA1, CT (SRA1, Steroid receptor RNA activator 1, Steroid receptor RNA activator protein) (Azide free) (HRP)
MBS6351019-5x02mL	MyBiosource	5x0.2mL	EUR 4250

RANK (Receptor Activator of NFkB) (Biotin)
MBS6249274-01mL	MyBiosource	0.1(mL	EUR 995

RANK (Receptor Activator of NFkB) (Biotin)
MBS6249274-5x01mL	MyBiosource	5x0.1mL	EUR 4325

Urokinase Plasminogen Activator Receptor (U Plasminogen Activator Receptor, UPA Receptor, uPAR, U-PAR, CD87, CD87 Antigen, MO3, Monocyte Activation Antigen Mo3, Plasminogen Activator Urokinase Receptor, PLAUR, URKR) (PE)
MBS632008-100Tests	MyBiosource	100Tests	EUR 800

Urokinase Plasminogen Activator Receptor (U Plasminogen Activator Receptor, UPA Receptor, uPAR, U-PAR, CD87, CD87 Antigen, MO3, Monocyte Activation Antigen Mo3, Plasminogen Activator Urokinase Receptor, PLAUR, URKR) (PE)
MBS632008-5x100Tests	MyBiosource	5x100Tests	EUR 3450

Urokinase Plasminogen Activator Receptor (uPAR, CD87, uPAR-1, PLAUR (plasminogen activator receptor, urokinase type)
MBS602151-01mg	MyBiosource	0.1mg	EUR 920

Urokinase Plasminogen Activator Receptor (uPAR, CD87, uPAR-1, PLAUR (plasminogen activator receptor, urokinase type)
MBS602151-05mg	MyBiosource	0.5mg	EUR 1870

Urokinase Plasminogen Activator Receptor (uPAR, CD87, uPAR-1, PLAUR (plasminogen activator receptor, urokinase type)
MBS602151-5x05mg	MyBiosource	5x0.5mg	EUR 8275

RANK (Receptor Activator of NFkB) (MaxLight 750)
MBS6257333-01mL	MyBiosource	0.1mL	EUR 995

RANK (Receptor Activator of NFkB) (MaxLight 750)
MBS6257333-5x01mL	MyBiosource	5x0.1mL	EUR 4325

RANK (Receptor Activator of NFkB) (MaxLight 550)
MBS6255254-01mL	MyBiosource	0.1(mL	EUR 995

RANK (Receptor Activator of NFkB) (MaxLight 550)
MBS6255254-5x01mL	MyBiosource	5x0.1mL	EUR 4325

RANK (Receptor Activator of NFkB) (MaxLight 650)
MBS6256294-01mL	MyBiosource	0.1(mL	EUR 995

RANK (Receptor Activator of NFkB) (MaxLight 650)
MBS6256294-5x01mL	MyBiosource	5x0.1mL	EUR 4325

RANK (Receptor Activator of NFkB) (MaxLight 405)
MBS6253174-01mL	MyBiosource	0.1(mL	EUR 995

RANK (Receptor Activator of NFkB) (MaxLight 405)
MBS6253174-5x01mL	MyBiosource	5x0.1mL	EUR 4325

RANK (Receptor Activator of NFkB) (MaxLight 490)
MBS6254214-01mL	MyBiosource	0.1(mL	EUR 995

RANK (Receptor Activator of NFkB) (MaxLight 490)
MBS6254214-5x01mL	MyBiosource	5x0.1mL	EUR 4325

Plasminogen Activator, Urokinase Receptor (uPAR)
MBS2025796-INQUIRE	MyBiosource	INQUIRE	Ask for price

uPAR (PLAU, ATF, UPA, URK, u-PA, Urokinase-Type Plasminogen Activator Receptor, Urokinase Plasminogen Activator Receptor) (AP)
MBS6442600-01mL	MyBiosource	0.1mL	EUR 950

uPAR (PLAU, ATF, UPA, URK, u-PA, Urokinase-Type Plasminogen Activator Receptor, Urokinase Plasminogen Activator Receptor) (AP)
MBS6442600-5x01mL	MyBiosource	5x0.1mL	EUR 4120

uPAR (PLAU, ATF, UPA, URK, u-PA, Urokinase-Type Plasminogen Activator Receptor, Urokinase Plasminogen Activator Receptor) (APC)
MBS6442601-01mL	MyBiosource	0.1mL	EUR 950

uPAR (PLAU, ATF, UPA, URK, u-PA, Urokinase-Type Plasminogen Activator Receptor, Urokinase Plasminogen Activator Receptor) (APC)
MBS6442601-5x01mL	MyBiosource	5x0.1mL	EUR 4120

uPAR (PLAU, ATF, UPA, URK, u-PA, Urokinase-Type Plasminogen Activator Receptor, Urokinase Plasminogen Activator Receptor) (HRP)
MBS6442604-01mL	MyBiosource	0.1mL	EUR 950

uPAR (PLAU, ATF, UPA, URK, u-PA, Urokinase-Type Plasminogen Activator Receptor, Urokinase Plasminogen Activator Receptor) (HRP)
MBS6442604-5x01mL	MyBiosource	5x0.1mL	EUR 4120

uPAR (PLAU, ATF, UPA, URK, u-PA, Urokinase-Type Plasminogen Activator Receptor, Urokinase Plasminogen Activator Receptor) (PE)
MBS6442610-01mL	MyBiosource	0.1mL	EUR 950

uPAR (PLAU, ATF, UPA, URK, u-PA, Urokinase-Type Plasminogen Activator Receptor, Urokinase Plasminogen Activator Receptor) (PE)
MBS6442610-5x01mL	MyBiosource	5x0.1mL	EUR 4120

Thrombin Receptor Activator Peptide 6 (TRAP-6)
MBS658098-5mg	MyBiosource	5mg	EUR 285

Thrombin Receptor Activator Peptide 6 (TRAP-6)
MBS658098-5x5mg	MyBiosource	5x5mg	EUR 1125

RANK, Recombinant, Human (Receptor Activator of NFkB)
MBS650880-0002mg	MyBiosource	0.002mg	EUR 340

RANK, Recombinant, Human (Receptor Activator of NFkB)
MBS650880-001mg	MyBiosource	0.01mg	EUR 490

RANK, Recombinant, Human (Receptor Activator of NFkB)
MBS650880-5x001mg	MyBiosource	5x0.01mg	EUR 2055

uPAR (PLAU, ATF, UPA, URK, u-PA, Urokinase-Type Plasminogen Activator Receptor, Urokinase Plasminogen Activator Receptor) (Biotin)
MBS6442602-01mL	MyBiosource	0.1mL	EUR 950

uPAR (PLAU, ATF, UPA, URK, u-PA, Urokinase-Type Plasminogen Activator Receptor, Urokinase Plasminogen Activator Receptor) (Biotin)
MBS6442602-5x01mL	MyBiosource	5x0.1mL	EUR 4120

uPAR (PLAU, ATF, UPA, URK, u-PA, Urokinase-Type Plasminogen Activator Receptor, Urokinase Plasminogen Activator Receptor) (FITC)
MBS6442603-01mL	MyBiosource	0.1mL	EUR 950

uPAR (PLAU, ATF, UPA, URK, u-PA, Urokinase-Type Plasminogen Activator Receptor, Urokinase Plasminogen Activator Receptor) (FITC)
MBS6442603-5x01mL	MyBiosource	5x0.1mL	EUR 4120

Urokinase plasminogen activator surface receptor
AP88839	SAB	1mg	EUR 2640

Urokinase plasminogen activator surface receptor
AP89121	SAB	1mg	EUR 2640

Urokinase plasminogen activator surface receptor
AP89196	SAB	1mg	EUR 2640

Urokinase plasminogen activator surface receptor
AP89271	SAB	1mg	EUR 2640

Active Plasminogen Activator, Urokinase Receptor (uPAR)
APA141Mu01	Cloud-Clone	10ug	EUR 212

Active Plasminogen Activator, Urokinase Receptor (uPAR)
APA141Ra01	Cloud-Clone	10ug	EUR 216

Urokinase Plasminogen Activator Receptor (uPA-R)
MBS621849-002mL	MyBiosource	0.02mL	EUR 395

Urokinase Plasminogen Activator Receptor (uPA-R)
MBS621849-01mL	MyBiosource	0.1mL	EUR 630

Urokinase Plasminogen Activator Receptor (uPA-R)
MBS621849-5x01mL	MyBiosource	5x0.1mL	EUR 2680

Steroid Receptor Rna Activator 1 (SRA) Antibody
abx115855-100g	Abbexa	100 µg	Ask for price

Steroid Receptor Rna Activator 1 (SRA) Antibody
abx115855-10g	Abbexa	10 µg	EUR 612.5

Steroid Receptor Rna Activator 1 (SRA) Antibody
20-abx115855	Abbexa	Ask for price Ask for price	50 ul 150 ul

Steroid Receptor Rna Activator 1 (SRA) Antibody
abx115855-200g	Abbexa	200 µg	Ask for price

Steroid Receptor Rna Activator 1 (SRA) Antibody
20-abx121756	Abbexa	Ask for price Ask for price Ask for price	30 ul 100 ul 200 ul

Steroid Receptor RNA Activator 1 (SRA1) Protein
20-abx263319	Abbexa	Ask for price Ask for price Ask for price	2 µg 10 ug 100 ug

Steroid Receptor RNA Activator 1 (SRA1) Protein
abx263319-10mg	Abbexa	10 mg	EUR 325

Steroid Receptor RNA Activator 1 (SRA1) Protein
abx263319-25mg	Abbexa	25 mg	EUR 1600

Steroid Receptor RNA Activator 1 (SRA1) Protein
abx263319-5mg	Abbexa	5 mg	EUR 225

Steroid Receptor Rna Activator 1 (SRA) Antibody
abx016058-100ul	Abbexa	100 ul	EUR 493.2

Steroid Receptor Rna Activator 1 (SRA) Antibody
abx016058-1mg	Abbexa	1 mg	EUR 362.5

Steroid Receptor Rna Activator 1 (SRA) Antibody
abx011567-100g	Abbexa	100 µg	Ask for price

Steroid Receptor Rna Activator 1 (SRA) Antibody
abx011567-100ul	Abbexa	100 ul	EUR 493.2

Steroid Receptor Rna Activator 1 (SRA) Antibody
abx011567-10g	Abbexa	10 µg	EUR 362.5

Steroid Receptor Rna Activator 1 (SRA) Antibody
abx011567-200g	Abbexa	200 µg	Ask for price

Thrombin Receptor Activator for Peptide 5 (TRAP-5)
A1036-10	ApexBio	10 mg	EUR 64
Description: Cardiovascular#Other Signal Transduction

Thrombin Receptor Activator for Peptide 5 (TRAP-5)
A1036-25	ApexBio	25 mg	EUR 88
Description: Cardiovascular#Other Signal Transduction

Thrombin Receptor Activator for Peptide 5 (TRAP-5)
A1036-5	ApexBio	5 mg	EUR 40
Description: Cardiovascular#Other Signal Transduction

Thrombin Receptor Activator for Peptide 5 (TRAP-5)
HY-P1536	MedChemExpress	10mg	EUR 445.2

Thrombin Receptor Activator for Peptide 5 (TRAP-5)
MBS3840675-10mg	MyBiosource	10mg	EUR 155

Thrombin Receptor Activator for Peptide 5 (TRAP-5)
MBS3840675-25mg	MyBiosource	25mg	EUR 180

Thrombin Receptor Activator for Peptide 5 (TRAP-5)
MBS3840675-5mg	MyBiosource	5mg	EUR 130

Thrombin Receptor Activator for Peptide 5 (TRAP-5)
MBS3840675-5x25mg	MyBiosource	5x25mg	EUR 790

Thrombin Receptor Activator for Peptide 5 (TRAP-5)
T7496-10mg	TargetMol Chemicals	10mg	Ask for price
Description: Thrombin Receptor Activator for Peptide 5 (TRAP-5)

Thrombin Receptor Activator for Peptide 5 (TRAP-5)
T7496-1g	TargetMol Chemicals	1g	Ask for price
Description: Thrombin Receptor Activator for Peptide 5 (TRAP-5)

Thrombin Receptor Activator for Peptide 5 (TRAP-5)
T7496-1mg	TargetMol Chemicals	1mg	Ask for price
Description: Thrombin Receptor Activator for Peptide 5 (TRAP-5)

Thrombin Receptor Activator for Peptide 5 (TRAP-5)
T7496-50mg	TargetMol Chemicals	50mg	Ask for price
Description: Thrombin Receptor Activator for Peptide 5 (TRAP-5)

Thrombin Receptor Activator for Peptide 5 (TRAP-5)
T7496-5mg	TargetMol Chemicals	5mg	Ask for price
Description: Thrombin Receptor Activator for Peptide 5 (TRAP-5)

Urokinase Plasminogen Activator Receptor (uPAR, CD87, PLAUR, MO3, Monocyte activation antigen Mo3, URKR, Urokinase Plasminogen Activator Surface Receptor)
MBS600292-01mg	MyBiosource	0.1mg	EUR 940

Urokinase Plasminogen Activator Receptor (uPAR, CD87, PLAUR, MO3, Monocyte activation antigen Mo3, URKR, Urokinase Plasminogen Activator Surface Receptor)
MBS600292-05mg	MyBiosource	0.5mg	EUR 1875

Urokinase Plasminogen Activator Receptor (uPAR, CD87, PLAUR, MO3, Monocyte activation antigen Mo3, URKR, Urokinase Plasminogen Activator Surface Receptor)
MBS600292-5x05mg	MyBiosource	5x0.5mg	EUR 8280

Steroid Receptor RNA Activator 1 (SRA1) Antibody
abx238212-100g	Abbexa	100 µg	EUR 350

Steroid Receptor RNA Activator 1 (SRA1) Antibody
abx238212-100ug	Abbexa	100 ug	EUR 661.2

Steroid Receptor RNA Activator 1 (SRA1) Antibody
abx238213-100g	Abbexa	100 µg	EUR 350

Steroid Receptor RNA Activator 1 (SRA1) Antibody
abx238213-100ug	Abbexa	100 ug	EUR 661.2

uPAR (PLAU, ATF, UPA, URK, u-PA, Urokinase-Type Plasminogen Activator Receptor, Urokinase Plasminogen Activator Receptor) (MaxLight 405)
MBS6442605-01mL	MyBiosource	0.1mL	EUR 950

uPAR (PLAU, ATF, UPA, URK, u-PA, Urokinase-Type Plasminogen Activator Receptor, Urokinase Plasminogen Activator Receptor) (MaxLight 405)
MBS6442605-5x01mL	MyBiosource	5x0.1mL	EUR 4120

uPAR (PLAU, ATF, UPA, URK, u-PA, Urokinase-Type Plasminogen Activator Receptor, Urokinase Plasminogen Activator Receptor) (MaxLight 490)
MBS6442606-01mL	MyBiosource	0.1mL	EUR 950

uPAR (PLAU, ATF, UPA, URK, u-PA, Urokinase-Type Plasminogen Activator Receptor, Urokinase Plasminogen Activator Receptor) (MaxLight 490)
MBS6442606-5x01mL	MyBiosource	5x0.1mL	EUR 4120

uPAR (PLAU, ATF, UPA, URK, u-PA, Urokinase-Type Plasminogen Activator Receptor, Urokinase Plasminogen Activator Receptor) (MaxLight 550)
MBS6442607-01mL	MyBiosource	0.1mL	EUR 950

uPAR (PLAU, ATF, UPA, URK, u-PA, Urokinase-Type Plasminogen Activator Receptor, Urokinase Plasminogen Activator Receptor) (MaxLight 550)
MBS6442607-5x01mL	MyBiosource	5x0.1mL	EUR 4120

uPAR (PLAU, ATF, UPA, URK, u-PA, Urokinase-Type Plasminogen Activator Receptor, Urokinase Plasminogen Activator Receptor) (MaxLight 650)
MBS6442608-01mL	MyBiosource	0.1mL	EUR 950

uPAR (PLAU, ATF, UPA, URK, u-PA, Urokinase-Type Plasminogen Activator Receptor, Urokinase Plasminogen Activator Receptor) (MaxLight 650)
MBS6442608-5x01mL	MyBiosource	5x0.1mL	EUR 4120

uPAR (PLAU, ATF, UPA, URK, u-PA, Urokinase-Type Plasminogen Activator Receptor, Urokinase Plasminogen Activator Receptor) (MaxLight 750)
MBS6442609-01mL	MyBiosource	0.1mL	EUR 950

uPAR (PLAU, ATF, UPA, URK, u-PA, Urokinase-Type Plasminogen Activator Receptor, Urokinase Plasminogen Activator Receptor) (MaxLight 750)
MBS6442609-5x01mL	MyBiosource	5x0.1mL	EUR 4120

Urokinase Plasminogen Activator Receptor (uPAR, CD87)
MBS605397-01mL	MyBiosource	0.1mL	EUR 925

Urokinase Plasminogen Activator Receptor (uPAR, CD87)
MBS605397-5x01mL	MyBiosource	5x0.1mL	EUR 4020

Urokinase Plasminogen Activator Receptor (uPAR, CD87)
MBS620704-01mg	MyBiosource	0.1mg	EUR 925

Urokinase Plasminogen Activator Receptor (uPAR, CD87)
MBS620704-5x01mg	MyBiosource	5x0.1mg	EUR 4015

Active Receptor Activator Of Nuclear Factor Kappa B (RANk)
APC057Hu01	Cloud-Clone	10ug	EUR 302

Active Receptor Activator Of Nuclear Factor Kappa B (RANk)
4-APC057Hu01	Cloud-Clone	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	5 mg 10ug 50ug 100 ug 200 ug 500 ug 1 mg
Description: Recombinant Human Receptor Activator Of Nuclear Factor Kappa B expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Receptor Activator Of Nuclear Factor Kappa B (RANk)
MBS2105163-001mg	MyBiosource	0.01mg	EUR 235

Active Receptor Activator Of Nuclear Factor Kappa B (RANk)
MBS2105163-005mg	MyBiosource	0.05mg	EUR 490

Active Receptor Activator Of Nuclear Factor Kappa B (RANk)
MBS2105163-01mg	MyBiosource	0.1mg	EUR 750

Active Receptor Activator Of Nuclear Factor Kappa B (RANk)
MBS2105163-02mg	MyBiosource	0.2mg	EUR 930

Active Receptor Activator Of Nuclear Factor Kappa B (RANk)
MBS2105163-05mg	MyBiosource	0.5mg	EUR 1800

Active Receptor Activator Of Nuclear Factor Kappa B (RANk)
RPU55749-100ug	Biomatik Corporation	100ug	EUR 936.1

Active Receptor Activator Of Nuclear Factor Kappa B (RANk)
RPU55749-1mg	Biomatik Corporation	1mg	EUR 4716.4

Active Receptor Activator Of Nuclear Factor Kappa B (RANk)
RPU55749-50ug	Biomatik Corporation	50ug	EUR 725.8

Rat Steroid Receptor RNA Activator 1 ELISA Kit
MBS1603442-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 3955

Rat Steroid Receptor RNA Activator 1 ELISA Kit
MBS1603442-48StripWells	MyBiosource	48-Strip-Wells	EUR 305

Rat Steroid Receptor RNA Activator 1 ELISA Kit
MBS1603442-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 2005

Rat Steroid Receptor RNA Activator 1 ELISA Kit
MBS1603442-96StripWells	MyBiosource	96-Strip-Wells	EUR 475

Recombinant Human Steroid Receptor RNA Activator 1
MBS146089-0002mg	MyBiosource	0.002mg	EUR 240

Recombinant Human Steroid Receptor RNA Activator 1
MBS146089-001mg	MyBiosource	0.01mg	EUR 310

Recombinant Human Steroid Receptor RNA Activator 1
MBS146089-01mg	MyBiosource	0.1mg	EUR 1360

Recombinant Human Steroid Receptor RNA Activator 1
MBS146089-5x01mg	MyBiosource	5x0.1mg	EUR 5800

Steroid Receptor RNA Activator 1 Human Recombinant
rAP-3861	Angio Proteomie	Inquiry	Ask for price

Plasminogen Activator, Urokinase Receptor (uPAR) Antibody
abx131796-100g	Abbexa	100 µg	EUR 775

Plasminogen Activator, Urokinase Receptor (uPAR) Antibody
20-abx131796	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	20 ug 50 ug 100 ug 200 ug 1 mg

Plasminogen Activator, Urokinase Receptor (uPAR) Antibody
abx131796-20g	Abbexa	20 µg	EUR 350

Plasminogen Activator, Urokinase Receptor (uPAR) Antibody
abx131796-5g	Abbexa	5 µg	EUR 275

Plasminogen Activator, Urokinase Receptor (uPAR) Antibody
abx131797-100g	Abbexa	100 µg	EUR 525

Plasminogen Activator, Urokinase Receptor (uPAR) Antibody
20-abx131797	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	20 ug 50 ug 100 ug 200 ug 1 mg

Plasminogen Activator, Urokinase Receptor (uPAR) Antibody
abx131797-20g	Abbexa	20 µg	EUR 275

Western blot was used to measure the expression of Bcl-2, Bax, pro-caspase-3 and cleaved caspase-3, and enzyme-linked immunosorbent assay (ELISA) is performed to detect inflammatory cytokines. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was used to detect the level of STAT3 and p65 mRNA. RESULTS baicalin reduce cell viability and induces apoptosis of HaCaT human keratinocytes in a dose-dependent manner.

The increase in cell survival and expression of inflammatory cytokines by HaCaT cells induced by TNF-alpha was significantly inhibited by baicalin. Baicalin significantly inhibited the activation of STAT3 / NF-kappaB in HaCaT cells stimulated by TNF-alpha. CONCLUSION baicalin inhibits proliferation and inflammatory cytokine expression in HaCaT immortalized human keratinocytes in vitro by inhibition of STAT3 / NF-kappaB signaling pathway.