Role of Nuclear factor kappa B (NF-κB) Signalling in Neurodegenerative Diseases: An Mechanistic Approach.

Role of Nuclear factor kappa B (NF-κB) Signalling in Neurodegenerative Diseases: An Mechanistic Approach.

A regulation of nuclear factor kappa B (NF-kB) is a transcription protein cellular modulators of biological activity through binding to the promoter region of the nucleus and copying various protein gene. Recent studies have involved intensive role of nuclear factor kappa B (NF-kB) in diseases such as autoimmune disorders, inflammatory, cardiovascular and neurodegenerative diseases.

Therefore, targeting the nuclear factor kappa B (NF-kB) offers new opportunities protein as a therapeutic approach. Activation of IκB kinase / NF-kB signaling pathway leads to the development of a variety of pathological conditions in humans, such as neurodegenerative, inflammatory disorders, autoimmune diseases and cancer.

Therefore, the transcriptional activity of IκB kinase / NF-kB are very organized in various lines cascade. Nuclear factor NF-kB pathway plays a major role in the expression of pro-inflammatory genes including cytokines, chemokines, and adhesion molecules. In response to diverse stimuli, exiled cytosolic NF-kB in an inactive form by binding to a protein molecule inhibitor (IKB) are phosphorylated and translocated to the nucleus of the transcript about the different genes required to modify various cellular functions.

Various studies confirm the role of different protein family members of the NF-kB is involved in the expression of various gene products and mediate various cellular cascades. MicroRNAs, as a regulator of NF kB microRNAs play an important role in the regulation of inflammatory processes. Therefore, inhibitors of NF-kB and family members play a new therapeutic target in preventing various diseases. Regulation of NF kB signaling pathway may be a treatment strategy that is safe and effective for various disorders.

Role of Nuclear factor kappa B (NF-κB) Signalling in Neurodegenerative Diseases: An Mechanistic Approach.
Role of Nuclear factor kappa B (NF-κB) Signalling in Neurodegenerative Diseases: An Mechanistic Approach.

Relieves asiaticoside Cerebral Ischemia-Reperfusion Injury through nod2 / mitogen-Activated Protein Kinase (MAPK) / Nuclear Factor kappa B (NF-kB) Signaling Pathway.

BACKGROUND Cerebral ischemia-reperfusion injury (FEATURE) is still a serious health problem. Centella formulations used to treat central nervous system disorders. In this study, asiaticoside, extracts from plants Centella asiatica, FEATURES investigated in vivo and in vitro. MATERIALS AND METHODS We modeled in vivo in mice FEATURES SD treated by middle cerebral artery occlusion, and cell models of ischemia-reperfusion injury was made in PC12 cells treated by a lack of oxygen and glucose / restoration. FEATURE vivo was assessed with a score of neurologic function, encephaledema, and the area of ​​cerebral infarction.

levels of inflammation and oxidative stress levels that are detected by the appropriate kit. TUNEL assay was performed to assess cell apoptosis and Western blot analysis was performed to assess the level of protein expression. CCK8 assay was performed to evaluate cell viability and flow cytometer is used to detect cell apoptosis in vitro.

RESULTS function of nerve injury, brain edema, cell apoptosis, infarct size, apoptosis- related protein expression and protein expression of nod2 / MAPK / NF-kappaB signaling pathway in the model MARKS all reversed by asiaticoside in rats. The apoptotic cells, the levels of inflammation and oxidative stress levels in models of ischemia-reperfusion injury to the brain is reduced asiaticoside. Effect of asiaticoside on FEATURE inverted by NOD-2 agonists.

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Anti - EP4 Receptor

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anti-5HT3B receptor

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EUR 435.6
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anti-5HT1E Receptor

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EUR 435.6
Description: Mouse polyclonal to 5HT1E Receptor

anti-5HT1A Receptor

YF-PA23931 50 ul
EUR 400.8
Description: Mouse polyclonal to 5HT1A Receptor

anti-5HT1B Receptor

YF-PA23932 50 ul
EUR 400.8
Description: Mouse polyclonal to 5HT1B Receptor

anti-5HT1F Receptor

YF-PA23933 50 ul
EUR 400.8
Description: Mouse polyclonal to 5HT1F Receptor

anti-5HT2B Receptor

YF-PA23934 50 ul
EUR 400.8
Description: Mouse polyclonal to 5HT2B Receptor

anti-5HT2C Receptor

YF-PA23935 50 ul
EUR 400.8
Description: Mouse polyclonal to 5HT2C Receptor

anti-C3a Receptor

YF-PA10565 50 ul
EUR 435.6
Description: Mouse polyclonal to C3a Receptor

anti-C3a Receptor

YF-PA10566 50 ug
EUR 435.6
Description: Mouse polyclonal to C3a Receptor

anti-C3a Receptor

YF-PA10567 100 ug
EUR 483.6
Description: Rabbit polyclonal to C3a Receptor

anti-EPO Receptor

YF-PA11609 50 ug
EUR 435.6
Description: Mouse polyclonal to EPO Receptor

anti-EPO Receptor

YF-PA11610 100 ug
EUR 483.6
Description: Rabbit polyclonal to EPO Receptor

anti-LDL Receptor

YF-PA12939 50 ug
EUR 435.6
Description: Mouse polyclonal to LDL Receptor

anti-EPO Receptor

YF-PA23657 50 ul
EUR 400.8
Description: Mouse polyclonal to EPO Receptor

anti-LDL Receptor

YF-PA24075 50 ul
EUR 400.8
Description: Mouse polyclonal to LDL Receptor

anti-MC1 Receptor

YF-PA24125 50 ul
EUR 400.8
Description: Mouse polyclonal to MC1 Receptor

anti-MC3 Receptor

YF-PA24126 50 ul
EUR 400.8
Description: Mouse polyclonal to MC3 Receptor

anti-GCSF Receptor

YF-PA11133 50 ul
EUR 435.6
Description: Mouse polyclonal to GCSF Receptor

anti-GCSF Receptor

YF-PA11134 50 ug
EUR 435.6
Description: Mouse polyclonal to GCSF Receptor

anti-GCSF Receptor

YF-PA11135 100 ug
EUR 483.6
Description: Rabbit polyclonal to GCSF Receptor

anti-IGF1 Receptor

YF-PA12619 100 ug
EUR 483.6
Description: Rabbit polyclonal to IGF1 Receptor

anti-BAFF Receptor

YF-PA21941 100 ug
EUR 483.6
Description: Rabbit polyclonal to BAFF Receptor

anti-Nogo Receptor

YF-PA20650 50 ul
EUR 435.6
Description: Mouse polyclonal to Nogo Receptor

anti-Nogo Receptor

YF-PA20651 50 ug
EUR 435.6
Description: Mouse polyclonal to Nogo Receptor

anti-Nogo Receptor

YF-PA20652 100 ul
EUR 483.6
Description: Rabbit polyclonal to Nogo Receptor

anti-Nogo Receptor

YF-PA20653 100 ug
EUR 483.6
Description: Rabbit polyclonal to Nogo Receptor

anti-GCSF Receptor

YF-PA23524 50 ul
EUR 400.8
Description: Mouse polyclonal to GCSF Receptor

anti-IGF1 Receptor

YF-PA23965 50 ul
EUR 400.8
Description: Mouse polyclonal to IGF1 Receptor

anti-NPFF2 Receptor

YF-PA17280 50 ug
EUR 435.6
Description: Mouse polyclonal to Anti-NPFF2 Receptor

anti-IL17A Receptor

YF-PA18054 50 ug
EUR 435.6
Description: Mouse polyclonal to IL17A Receptor

anti-IL17B Receptor

YF-PA26340 50 ul
EUR 400.8
Description: Mouse polyclonal to IL17B Receptor

Anti-Leukotriene B4 Receptor(BLT1 Receptor) Antibody

Y080007 100 µl
EUR 125

anti-Leptin Receptor

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Description: Mouse polyclonal to Leptin Receptor

Anti - Orexin 2 Receptor (Hypocretin 2 Receptor)

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Anti - Orexin 2 Receptor (Hypocretin 2 Receptor)

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Anti - Orexin 1 Receptor (Hypocretin 1 Receptor)

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Anti - Orexin 1 Receptor (Hypocretin 1 Receptor)

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anti-Mannose Receptor

YF-PA24168 50 ul
EUR 400.8
Description: Mouse polyclonal to Mannose Receptor

Anti-Glycine Receptor

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Anti-Glycine Receptor

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anti-Thrombin Receptor

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anti-Thrombin Receptor

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EUR 483.6
Description: Rabbit polyclonal to Thrombin Receptor

anti-androgen receptor

YF-PA23237 50 ul
EUR 400.8
Description: Mouse polyclonal to androgen receptor

anti-Prolactin Receptor

YF-PA14044 50 ul
EUR 435.6
Description: Mouse polyclonal to Prolactin Receptor

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YF-PA14045 100 ug
EUR 483.6
Description: Rabbit polyclonal to Prolactin Receptor

anti-Calcitonin receptor

YF-PA10626 50 ug
EUR 435.6
Description: Mouse polyclonal to Calcitonin receptor

anti-Calcitonin receptor

YF-PA10627 100 ug
EUR 483.6
Description: Rabbit polyclonal to Calcitonin receptor

anti-Poliovirus receptor

YF-PA14226 100 ug
EUR 483.6
Description: Rabbit polyclonal to Poliovirus receptor

anti-Poliovirus receptor

YF-PA24528 50 ul
EUR 400.8
Description: Mouse polyclonal to Poliovirus receptor

anti-Progesterone Receptor

YF-PA24362 50 ul
EUR 400.8
Description: Mouse polyclonal to Progesterone Receptor

Anti - Leptin Receptor (OBR, LEPR, B219, Obese Receptor)

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Anti - Leptin Receptor (OBR, LEPR, B219, Obese Receptor)

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Anti - Leptin Receptor (OBR, LEPR, B219, Obese Receptor)

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Anti - Leptin Receptor (OBR, LEPR, B219, Obese Receptor)

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Anti - Leptin Receptor (OBR, LEPR, B219, Obese Receptor)

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Anti - Leptin Receptor (OBR, LEPR, B219, Obese Receptor)

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Anti - Leptin Receptor (OBR, LEPR, B219, Obese Receptor)

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Anti - Leptin Receptor (OBR, LEPR, B219, Obese Receptor)

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Anti - Leptin Receptor (OBR, LEPR, B219, Obese Receptor)

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Anti - Leptin Receptor (OBR, LEPR, B219, Obese Receptor)

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anti-Glucocorticoid Receptor

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anti-Eph receptor A2

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EUR 435.6
Description: Mouse polyclonal to Eph receptor A2

anti-Eph receptor A2

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anti-Eph receptor A2

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EUR 483.6
Description: Rabbit polyclonal to Eph receptor A2

anti-Eph receptor A3

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EUR 435.6
Description: Mouse polyclonal to Eph receptor A3

anti-Eph receptor A7

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EUR 435.6
Description: Mouse polyclonal to Eph receptor A7

anti-Eph receptor A7

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EUR 483.6
Description: Rabbit polyclonal to Eph receptor A7

anti-Eph receptor B1

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EUR 435.6
Description: Mouse polyclonal to Eph receptor B1

anti-Eph receptor B1

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Description: Mouse polyclonal to Eph receptor B1

anti-Eph receptor B3

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EUR 435.6
Description: Mouse polyclonal to Eph receptor B3

anti-Eph receptor B3

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EUR 435.6
Description: Mouse polyclonal to Eph receptor B3

anti-TNF Receptor II

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EUR 435.6
Description: Mouse polyclonal to TNF Receptor II

anti-TNF Receptor II

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Description: Mouse polyclonal to TNF Receptor II

anti-TNF Receptor II

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anti-VIP Receptor 1

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Description: Mouse polyclonal to VIP Receptor 1

anti-VIP Receptor 1

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anti-VIP Receptor 1

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EUR 483.6
Description: Rabbit polyclonal to VIP Receptor 1

anti-IL1 Receptor II

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EUR 435.6
Description: Mouse polyclonal to IL1 Receptor II

anti-IL1 Receptor II

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EUR 483.6
Description: Rabbit polyclonal to IL1 Receptor II

anti-IL1 Receptor I

YF-PA12662 50 ug
EUR 435.6
Description: Mouse polyclonal to IL1 Receptor I

anti-Eph receptor A2

YF-PA23631 50 ul
EUR 400.8
Description: Mouse polyclonal to Eph receptor A2

anti-Eph receptor A1

YF-PA23652 50 ul
EUR 400.8
Description: Mouse polyclonal to Eph receptor A1

anti-Eph receptor A4

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EUR 400.8
Description: Mouse polyclonal to Eph receptor A4

anti-Eph receptor B2

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EUR 400.8
Description: Mouse polyclonal to Eph receptor B2

anti-Eph receptor B3

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EUR 400.8
Description: Mouse polyclonal to Eph receptor B3

anti-Eph receptor B6

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EUR 400.8
Description: Mouse polyclonal to Eph receptor B6

anti-IL1 Receptor I

YF-PA23973 50 ul
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Description: Mouse polyclonal to IL1 Receptor I

anti-IL1 Receptor II

YF-PA25014 50 ul
EUR 400.8
Description: Mouse polyclonal to IL1 Receptor II

Anti-5HT1E Receptor (2E9)

YF-MA13614 100 ug
EUR 435.6
Description: Mouse monoclonal to 5HT1E Receptor

Anti-5HT2B Receptor (4F3)

YF-MA13615 100 ug
EUR 435.6
Description: Mouse monoclonal to 5HT2B Receptor

Anti-5HT2C Receptor (1A8)

YF-MA13616 100 ug
EUR 435.6
Description: Mouse monoclonal to 5HT2C Receptor

Anti-5HT5A receptor (3D1)

YF-MA13618 100 ug
EUR 435.6
Description: Mouse monoclonal to 5HT5A receptor

Anti-IP Receptor Antibody

Y080040 100 µl
EUR 125

Anti-TP Receptor Antibody

Y080044 100 µl
EUR 125

Anti-IP Receptor antibody

STJ93743 200 µl
EUR 236.4
Description: Rabbit polyclonal to IP Receptor.

Anti-Ah Receptor antibody

STJ91510 200 µl
EUR 236.4
Description: Rabbit polyclonal to Ah Receptor.

Anti-IP Receptor Antibody

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Anti-IP Receptor Antibody

MBS8243115-01mL 0.1mL
EUR 255

Anti-IP Receptor Antibody

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Anti-IP Receptor Antibody

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Anti-Ah Receptor Antibody

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Anti-Ah Receptor Antibody

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EUR 255

Anti-Ah Receptor Antibody

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Anti-Ah Receptor Antibody

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Anti-LH Receptor Antibody

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Anti-LH Receptor Antibody

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Anti-LH Receptor Antibody

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Anti-LH Receptor Antibody

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Anti-IP Receptor Antibody

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Anti-IP Receptor Antibody

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anti-VEGF Receptor 1

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EUR 435.6
Description: Mouse polyclonal to VEGF Receptor 1

anti-VEGF Receptor 1

YF-PA11818 100 ug
EUR 483.6
Description: Rabbit polyclonal to VEGF Receptor 1

anti-p75 NGF Receptor

YF-PA13443 100 ug
EUR 483.6
Description: Rabbit polyclonal to p75 NGF Receptor

anti-VEGF Receptor 3

YF-PA23727 50 ul
EUR 400.8
Description: Mouse polyclonal to VEGF Receptor 3

Anti-LDL Receptor (5E7)

YF-MA10514 100 ug
EUR 435.6
Description: Mouse monoclonal to LDL Receptor

Anti-EPO Receptor (3F6)

YF-MA12883 100 ug
EUR 435.6
Description: Mouse monoclonal to EPO Receptor

Anti-LDL Receptor (5E6)

YF-MA13968 50 ug
EUR 435.6
Description: Mouse monoclonal to LDL Receptor

Anti-LDL Receptor (5E6)

YF-MA13969 200 ul
EUR 435.6
Description: Mouse monoclonal to LDL Receptor

Anti-D2 Receptor FITC

STJ500711 100 µg
EUR 703.2

Anti - GPR14 (UII Receptor)

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Anti - GPR14 (UII Receptor)

MBS621738-5x01mg 5x0.1mg
EUR 3465

Anti-5HT5A receptor (10D3)

YF-MA13617 100 ug
EUR 435.6
Description: Mouse monoclonal to 5HT5A receptor

Anti-DP1 receptor Antibody

Y080009 100 µl
EUR 125

Anti-EP3 Receptor Antibody

Y080027 100 µl
EUR 125

Anti-CB1 Receptor Antibody

Y080037 100 µl
EUR 125

Anti-EP4 Receptor Antibody

Y080075 100 µl
EUR 125

Anti-EP2 Receptor Antibody

Y080091 100 µl
EUR 125

Anti-IP3 Receptor Antibody

ER1803-17 100ul
EUR 189
Description: Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.

Anti-LDL Receptor Antibody

R1512-12 100ul
EUR 189
Description: LDLR (low density lipoprotein receptor) is a member of the LDL receptor gene family, which includes LDLR, LRP, Megalin, VLDLR, and ApoER2. The LDL receptor family is characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats, and an O-linked sugar domain. The LDL receptor is a cell surface transmembrane protein that mediates the uptake of low density lipoprotein and its degradation in the lysosome, which provides cholesterol to cells. The cytoplasmic domain of the LDL receptor is necessary for the receptor to cluster in coated pits, which promotes the rapid endocytosis of bound LDL. Mutations in LDLR cause the autosomal dominant disease, familial hypercholesterolemia (FH), which promotes premature coronary atherosclerosis.

Anti-EGF Receptor antibody

STJ99227 200 µl
EUR 236.4
Description: Mouse monoclonal to EGF Receptor.

Anti-EGF Receptor antibody

STJ99228 200 µl
EUR 236.4
Description: Mouse monoclonal to EGF Receptor.

Anti-EGF Receptor antibody

STJ99229 200 µl
EUR 236.4
Description: Mouse monoclonal to EGF Receptor.

Anti-EGF Receptor antibody

STJ99230 200 µl
EUR 236.4
Description: Mouse monoclonal to EGF Receptor.

Anti-GIP Receptor Antibody

MBS8242053-003mL 0.03mL
EUR 185

Anti-GIP Receptor Antibody

MBS8242053-01mL 0.1mL
EUR 255

Anti-GIP Receptor Antibody

MBS8242053-02mL 0.2mL
EUR 335

Anti-GIP Receptor Antibody

MBS8242053-5x02mL 5x0.2mL
EUR 1420

Anti-MC5 Receptor Antibody

MBS8242118-003mL 0.03mL
EUR 185

Anti-MC5 Receptor Antibody

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EUR 255

Anti-MC5 Receptor Antibody

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EUR 335

Anti-MC5 Receptor Antibody

MBS8242118-5x02mL 5x0.2mL
EUR 1420

Anti-MC4 Receptor Antibody

MBS821308-003mL 0.03mL
EUR 185

Anti-MC4 Receptor Antibody

MBS821308-01mL 0.1mL
EUR 255

Anti-MC4 Receptor Antibody

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EUR 335

Anti-MC4 Receptor Antibody

MBS821308-5x02mL 5x0.2mL
EUR 1420

Anti-EPO Receptor Antibody

MBS8242459-003mL 0.03mL
EUR 185

Anti-EPO Receptor Antibody

MBS8242459-01mL 0.1mL
EUR 255

Anti-EPO Receptor Antibody

MBS8242459-02mL 0.2mL
EUR 335

Anti-EPO Receptor Antibody

MBS8242459-5x02mL 5x0.2mL
EUR 1420

Anti-MC3 Receptor Antibody

MBS8291709-005mL 0.05mL
EUR 210

CONCLUSION Asiaticoside shown a protective effect against ischemia-reperfusion injury of the brain through nod2 / MAPK / NF-kappaB signaling pathway. These findings are particularly important for future research on the use of asiaticoside in MARKS, providing a new way to reduce FEATURES.

Megan

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